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What is Curcumin Analogues Inhibit Human GSTs about?

This study investigates the inhibitory effects of curcumin and 34 synthetic curcumin analogues on human glutathione S-transferases (GSTs), which are crucial for detoxifying harmful compounds. The results indicate that while most analogues show weaker inhibition than curcumin, certain compounds exhibit significant potency against specific GST isoenzymes, with IC50 values ranging from 0.2 to 4.6 μM. Additionally, the study employs quantitative structure–activity relationship (QSAR) analyses to identify molecu

Author

makitrabalhos

Language

EN