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Effect of Immunotherapy-infusion Time of Day on Survival of Patients with Advanced Cancers: a Study-level Meta-analysis by T. Landré; A. Karaboué; Z.S. Buchwald; P.F. Innominato; D.C. Qian; J.B. Assié; C. Chouaïd; F. Lévi; B. Duchemann is a Medicine article available to read on EtoBox.

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## Background Immune checkpoint inhibitors (ICIs) have become the standard of care for numerous malignancies. Emerging evidence suggests that the time of day (ToD) of ICI administration could impact the outcomes of patients with cancer. The consistency of ToD effects on ICI efficacy awaits initial evaluation. ## Materials and methods This meta-analysis integrates progression-free survival (PFS) and overall survival (OS) data from studies with a defined ‘cut-off’ ToD. Hazard ratios (HRs) [95% confidence interval (CI)] of an earlier progression or death according to ‘early’ or ‘late’ ToD of ICIs were collected from each report and pooled. ## Results Thirteen studies involved 1663 patients (Eastern Cooperative Oncology Group performance status 0-1, 83%; males/females, 67%/33%) with non-small-cell lung cancer (47%), renal cell carcinoma (24%), melanoma (20%), urothelial cancer (5%), or esophageal carcinoma (4%). Most patients received anti-programmed cell death protein 1 or anti-programmed death-ligand 1 (98%), and a small proportion also received anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) (18%). ToD cut-offs were 13:00 or 14:00 (i.e. ICI median infusion time), for

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Author

T. Landré; A. Karaboué; Z.S. Buchwald; P.F. Innominato; D.C. Qian; J.B. Assié; C. Chouaïd; F. Lévi; B. Duchemann

Publisher

Elsevier

Published

2024

Language

EN

Field

Medicine (Health Sciences)