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Single-breath Exhaled Nitric Oxide in Preschool Children Facilitated by a Servo-controlled Device Maintaining Constant Flow by Philip E. Silkoff; Christopher A. Bates; John B. Meiser; Donna L. Bratton is a Medicine article available to read on EtoBox.

What is Single-breath Exhaled Nitric Oxide in Preschool Children Facilitated by a Servo-controlled Device Maintaining Constant Flow about?

## Abstract Fractional concentration of exhaled nitric oxide (FE~NO~), an index of airway inflammation, is optimally measured in adults and school‐age children using a single‐breath online (SBOL) exhalation at constant flow. However, preschool‐aged (<6 years old) children have difficulty exhaling at constant flow, and alternative methods are needed. We employed a servo‐controlled variable resistance device (servo device) that controls expiratory flow while allowing the child to vary expiratory pressure. To validate this device, 8 children (aged 6–12 years) performed SBOL exhalations with and without the servo device at expired flow rates between 20–50 ml/sec. We then studied 32 young children aged 24–71 months with the servo device alone at exhalation flows of 30, 40, and 50 ml/sec. Test difficulty (TD) with each method was rated by questioning the older children, or as observed by the physician obtaining the data in the younger children (0 = no difficulty, 1 = mild difficulty, 2 = moderate difficulty, and 3 = unable to perform test). In the older children, SBOL exhalations with and without the servo device demonstrated equivalent flow‐dependence of FE~NO~ values. Test difficulty w

Who reads Single-breath Exhaled Nitric Oxide in Preschool Children Facilitated by a Servo-controlled Device Maintaining Constant Flow?

Author

Philip E. Silkoff; Christopher A. Bates; John B. Meiser; Donna L. Bratton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

2004

Language

EN

Field

Medicine (Health Sciences)