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The Effect of Melatonin on Incretin Hormones: Results From Experimental and Randomized Clinical Studies by Esben Stistrup Lauritzen; Julie Støy; Cecilie Bæch-Laursen; Niels Grarup; Niels Jessen; Torben Hansen; Niels Møller; Bolette Hartmann; Jens Juul Holst; Ulla Kampmann is a Medicine article available to read on EtoBox.
What is The Effect of Melatonin on Incretin Hormones: Results From Experimental and Randomized Clinical Studies about?
## Abstract ## Context Glucose homeostasis is under circadian control through both endocrine and intracellular mechanisms, with several lines of evidence suggesting that melatonin affects glucose homeostasis. ## Objective To evaluate the acute in vivo and in situ effects of melatonin on secretion of the incretin hormones, glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), and their impact on β-cell insulin secretion. ## Design A human randomized, double-blinded, placebo-controlled crossover study combined with a confirmatory in situ study of perfused rat intestines. ## Setting Aarhus University Hospital. ## Methods Fifteen healthy male participants were examined 2 × 2 times: an oral glucose tolerance test (OGTT) was performed on day 1 and an isoglycemic IV glucose infusion replicating the blood glucose profile of the OGTT day was performed on day 2. These pairs of study days were repeated on treatment with melatonin and placebo, respectively. For the in situ study, 6 rat intestines and 4 rat pancreases were perfused arterially with perfusion buffer ± melatonin. The intestines were concomitantly perfused with glucose through the luminal compartment.
Who reads The Effect of Melatonin on Incretin Hormones: Results From Experimental and Randomized Clinical Studies?
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- Author
- Esben Stistrup Lauritzen; Julie Støy; Cecilie Bæch-Laursen; Niels Grarup; Niels Jessen; Torben Hansen; Niels Møller; Bolette Hartmann; Jens Juul Holst; Ulla Kampmann
- Publisher
- The Endocrine Society
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)