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Real-world data of HER2-low metastatic breast cancer: A population based cohort study by Emily I. Holthuis; Gerard T. Vondeling; Josephina G. Kuiper; Vincent Dezentjé; Mats Rosenlund; Jetty A. Overbeek; Carolien H.M. van Deurzen is a Medicine article available to read on EtoBox.

What is Real-world data of HER2-low metastatic breast cancer: A population based cohort study about?

## Background With the introduction of investigational human epidermal growth factor receptor 2 (HER2) targeting treatments, thorough understanding of breast cancer with different HER2 expression levels is critical. The aim of this study was to compare clinicopathologic characteristics and survival of patients with metastatic breast cancer according to the level of HER2 expression. ## Methods Women with distant metastatic breast cancer during 2008–2016 were selected from PALGA, the Dutch Pathology Registry, and linked to the PHARMO Database Network. Breast cancer samples were categorised as HER2 immunohistochemistry score 0 (IHC0), HER2-low or HER2+. ## Results Among women with hormone receptor (HR) positive metastatic breast cancer (n = 989), 373 (38%) cancers were HER2 IHC0, 472 (48%) were HER2-low and 144 (15%) were HER2+. Among HR negative patients (n = 272), the proportion of HER2 IHC0, HER2-low and HER2+ was 110 (40%), 104 (38%) and 58 (21%) respectively. Within the HR + cohort, patients with HER2 IHC0 or HER2-low cancer were significantly older compared to HER2+ patients. This age difference was not seen in the HR-cohort. The localisation of distant metastases differed signi

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Author

Emily I. Holthuis; Gerard T. Vondeling; Josephina G. Kuiper; Vincent Dezentjé; Mats Rosenlund; Jetty A. Overbeek; Carolien H.M. van Deurzen

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)