Can I read Current trends in PLGA based long-acting injectable products: The industry perspective on EtoBox?

Current trends in PLGA based long-acting injectable products: The industry perspective by Omkara Swami Muddineti; Abdelwahab Omri is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Current trends in PLGA based long-acting injectable products: The industry perspective about?

Introduction: Poly(lactic-co-glycolic acid) (PLGA) has been used in many long-acting drug formulations, which have been approved by the US Food and Drug Administration (FDA). PLGA has unique physicochemical properties, which results in complexities in the formulation, characterization, and evaluation of generic products. To address the challenges of generic development of PLGA-based products, the FDA has established an extensive research program to investigate novel methods and tools to aid product development and regulatory review. Areas covered: This review article intends to provide a comprehensive review on physicochemical properties of PLGA polymer, characterization, formulation, analytical aspects, manufacturing conditions on product performance, in-vitro release testing, and bioequivalence. Current research on formulation development was done as per QbD in vitro release testing methods, regulatory research outcomes, and bioequivalence. Expert opinion: The development of PLGA-based long-acting injectables is promising and challenging when considering the numerous interrelated delivery-related factors. Achieving a successful formulation requires a thorough understanding of the

Who reads Current trends in PLGA based long-acting injectable products: The industry perspective?

Author

Omkara Swami Muddineti; Abdelwahab Omri

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)