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Determination of 2-Chloro-4,5-difluorobenzoic Acid and Related Impurities by Liquid Chromatography by Lee Elrod Jr.; Stephen G. Spanton; Moike Cirovic; Dean I. Shaffer; Timothy G. Golich; Cathie L. Linton; Douglas R. Vievia; Pano Kalaritis; Horst Schmand is a Chemistry article available to read on EtoBox.
What is Determination of 2-Chloro-4,5-difluorobenzoic Acid and Related Impurities by Liquid Chromatography about?
2-Chloro-4,5-difluorobenxoic acid (CDFBA) and related impurities are determined using liquid chromatography (LC). Separations are achieved using a reversed-phase isocratic system with an ion-pair reagent (tetrabutylammonium hydroxide). Unique isomeric impurities observed in commercially produced CDPBA were isolated and identified by NMR and single crystal x-ray diffraction. The method has relative standard deviations of f 0.55% to f 1.26% for the CDPBA determination and from \*4.3% to f 12% for impurities below 0.3% in CDPBA. Impurities are determinable to at least 0.03% by weight.
Who reads Determination of 2-Chloro-4,5-difluorobenzoic Acid and Related Impurities by Liquid Chromatography?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Lee Elrod Jr.; Stephen G. Spanton; Moike Cirovic; Dean I. Shaffer; Timothy G. Golich; Cathie L. Linton; Douglas R. Vievia; Pano Kalaritis; Horst Schmand
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0003-2670)
- Published
- 1993
- Language
- EN
- Field
- Chemistry (Physical Sciences)