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This document describes research into the total synthesis of crenulatan diterpenes. It outlines the strategy of using the chirality in (S)-citronellol to control the stereochemistry. Key steps include the efficient conversion of (S)-citronellol to an allylated alcohol, accessing an α,β-unsaturated lactone, and performing a stereocontrolled conjugate addition to introduce a hydroxymethyl group. Further reactions allow construction of the bicyclic keto-lactone building block.

Author

Libre Joel Ian

Language

EN