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Bladder Carcinomas in Patients with Neurogenic Bladder and Urinary Schistosomiasis: Are They the Same Tumors? by Fabiana Cancrini; Floriane Michel; Olivier Cussenot; Hussa Alshehhi; Eva Comperat; Véronique Phé is a Medicine article available to read on EtoBox.
What is Bladder Carcinomas in Patients with Neurogenic Bladder and Urinary Schistosomiasis: Are They the Same Tumors? about?
Purpose The aim of our study was to evaluate and compare the expression of different immunohistochemical markers in Bladder Carcinomas (BC) in patients with Neurogenic Bladder (NB) and Urinary Schistosomiasis (US) infection. Materials and methods We collected tissue samples from patients with Neurogenic Bladder and Bladder Carcinoma (NBC Group) and from patients with Urinary Schistosomiasis infection and Bladder Carcinoma (SBC Group). We compared to these two groups to control samples from resection from patients with Urinary Schistosomiasis without Bladder Carcinoma (US Group); we also investigate patients' characteristics according to urothelial transitional cell carcinoma (TCC), and squamous cell carcinoma (SCC) histopathological differentiation. The expression of markers in all groups (CK7, CK14, CK20, FoxP3, GATA3, STAG2, CD3, CD8, Ki67, and P53) was analyzed using immunohistochemistry of tissue microarray sections (TMA). Results Overall, 136 patients were included in the study (n = 72 in the NBC group, n = 33 in the SBC group, and n = 31 in the US group). In the TCC subgroup, the expression of CK7, CK14, CK20, and Ki67 was significantly higher compared to US controls (p 0.002
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- Author
- Fabiana Cancrini; Floriane Michel; Olivier Cussenot; Hussa Alshehhi; Eva Comperat; Véronique Phé
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)