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Can I read In vitro activity of tigecycline and comparators against carbapenem-susceptible and resistant Acinetobacter baumannii clinical isolates in Italy on EtoBox?

In vitro activity of tigecycline and comparators against carbapenem-susceptible and resistant Acinetobacter baumannii clinical isolates in Italy by Lina Maria Mezzatesta; Giusi Trovato; Floriana Gona; Vito Mar Nicolosi; Daria Nicolosi; Alessandra Carattoli; Giovanni Fadda; Giuseppe Nicoletti; Stefania Stefani is a Medicine article available to read on EtoBox.

What is In vitro activity of tigecycline and comparators against carbapenem-susceptible and resistant Acinetobacter baumannii clinical isolates in Italy about?

## Background In a recent multi-centre Italian survey (2003–2004), conducted in 45 laboratories throughout Italy with the aim of monitoring microorganisms responsible for severe infections and their antibiotic resistance, __Acinetobacter baumannii__ was isolated from various wards of 9 hospitals as one of the most frequent pathogens. One hundred and seven clinically significant strains of __A. baumannii__ isolates were included in this study to determine the __in vitro__ activity of tigecycline and comparator agents. ## Methods Tests for the susceptibility to antibiotics were performed by the broth microdilution method as recommended by CLSI guidelines. The following antibiotics were tested: aztreonam, piperacillin/tazobactam, ampicillin/sulbactam, ceftazidime, cefepime, imipenem, meropenem tetracycline, doxycycline, tigecycline, gentamicin, amikacin, ciprofloxacin, colistin, and trimethoprim/sulphametoxazole. The PCR assay was used to determine the presence of OXA, VIM, or IMP genes in the carbapenem resistant strains. ## Results __A. baumannii__ showed widespread resistance to ceftazidime, ciprofloxacin and aztreonam in more than 90% of the strains; resistance to imipenem and mer

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Author
Lina Maria Mezzatesta; Giusi Trovato; Floriana Gona; Vito Mar Nicolosi; Daria Nicolosi; Alessandra Carattoli; Giovanni Fadda; Giuseppe Nicoletti; Stefania Stefani
Publisher
BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2002]-; Springer Science and Business Media LLC; Springer Nature (ISSN 1476-0711)
Published
2008
Language
EN
Field
Medicine (Health Sciences)