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Can I read Effects of Photodynamic Therapy Using Topical Applied Hexylaminolevulinate and Methylaminolevulinate Upon the Integrity of Cervical Epithelium on EtoBox?
Effects of Photodynamic Therapy Using Topical Applied Hexylaminolevulinate and Methylaminolevulinate Upon the Integrity of Cervical Epithelium by Philipp Soergel; Regine Loehr-Schulz; Marija Hillemanns; Sandra Landwehr; Lars Makowski; Peter Hillemanns is a Medicine article available to read on EtoBox.
What is Effects of Photodynamic Therapy Using Topical Applied Hexylaminolevulinate and Methylaminolevulinate Upon the Integrity of Cervical Epithelium about?
## Abstract ## Background and Objective Cervical intraepithelial neoplasia (CIN) is associated with genital human papillomavirus (HPV) infection and represents the precursor of cervical cancer. Established ablative treatment methods may cause substantial complications in following pregnancies including premature delivery and the birth of low‐weight babies. Photodynamic therapy (PDT) of CIN using esters of 5‐aminolevulinic acid (5‐ALA) represents a promising alternative. However, it has not been analyzed yet if the PDT itself leads to sustained damage of the cervical tissue. This study aims at evaluating the effect of hexylaminolevulinate (HAL) and methylaminolevulinate (MAL) PDT on cervical tissue. ## Study Design/Materials and Methods Twenty‐five patients underwent 1–2 PDT cycles for CIN 1–3 applying topical HAL and MAL. Before and 6 months after PDT, biopsies were obtained from the cervix. Macroscopic changes of the cervix were evaluated. We assessed H&E slides for signs of sustained tissue damage. Furthermore, expression profiles of p16^INK4a^, Ki67, Bcl‐2, Bax, and CD31 were evaluated. ## Results PDT was performed satisfactory in all patients. No macroscopic changes of the cerv
Who reads Effects of Photodynamic Therapy Using Topical Applied Hexylaminolevulinate and Methylaminolevulinate Upon the Integrity of Cervical Epithelium?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Philipp Soergel; Regine Loehr-Schulz; Marija Hillemanns; Sandra Landwehr; Lars Makowski; Peter Hillemanns
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)