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Can I read Aneuploidy and Cancer on EtoBox?
Aneuploidy and Cancer by Ya‐Hui Chi; Kuan‐Teh Jeang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Aneuploidy and Cancer about?
## Abstract The cell's euploid status is influenced by, amongst other mechanisms, an intact spindle assembly checkpoint (SAC), an accurate centrosome cycle, and proper cytokinesis. Studies in mammalian cells suggest that dysregulated SAC function, centrosome cycle, and cytokinesis can all contribute significantly to aneuploidy. Of interest, human cancers are frequently aneuploid and show altered expression in SAC genes. The SAC is a multi‐protein complex that monitors against mis‐segregation of sister chromatids. Several recent experimental mouse models have suggested a link between weakened SAC and in vivo tumorigenesis. Here, we review in brief some mechanisms which contribute to cellular aneuploidy and offer a perspective on the relationship between aneuploidy and human cancers. J. Cell. Biochem. 102: 531–538, 2007. © 2007 Wiley‐Liss, Inc.
Who reads Aneuploidy and Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ya‐Hui Chi; Kuan‐Teh Jeang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)