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Circulating mRNA and microRNA profiling analysis in patients with ischemic stroke by Sujuan Sun; Litao Li; Lipeng Dong; Jinming Cheng; Congying Zhao; Chu Bao; Hebo Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Circulating mRNA and microRNA profiling analysis in patients with ischemic stroke about?

To provide insight into molecular diagnosis and individualized treatment of ischemic stroke (IS), several available datasets in IS were analyzed to identify the differentially expressed genes and microRNAs (miRNAs). Series matrix files from GSE22255 and GSE16561 (mRNA profiles), a well as GSE110993 (miRNA profile) were downloaded from the Gene Expression Omnibus database. System-level clustering was performed with GeneCluster 3.0 software, and gene annotation and pathway enrichment were performed with gene ontology analysis and Database for Annotation, Visualization and Integrated Discovery software. For a protein-protein interaction (PPI) network, Biological General Repository for Interaction Datasets and IntAct interaction information were integrated to determine the interaction of differentially expressed genes. The selected miRNA candidates were imported into the TargetScan, miRDB and miRecords databases for the prediction of target genes. The present study identified 128 upregulated and 231 downregulated genes in female stroke patients, and 604 upregulated and 337 downregulated genes in male stroke patients compared with sex- and age-matched controls. The construction of a PPI

Who reads Circulating mRNA and microRNA profiling analysis in patients with ischemic stroke?

Author

Sujuan Sun; Litao Li; Lipeng Dong; Jinming Cheng; Congying Zhao; Chu Bao; Hebo Wang

Publisher

Spandidos Publications

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)