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Osteoconductive modifications of Ti-implants in a goat defect model: characterization of bone growth with SR μCT and histology by Ricardo Bernhardt; Juliette van den Dolder; Sussane Bierbaum; Rene Beutner; Dieter Scharnweber; John Jansen; Felix Beckmann; Hartmut Worch is a Engineering article available to read on EtoBox.
What is Osteoconductive modifications of Ti-implants in a goat defect model: characterization of bone growth with SR μCT and histology about?
In this work the osteoconductive potential of coatings for titanium implants using different extracellular matrix components was evaluated. Cylindrical implants with two defined cavities A and B were coated with collagen type I, type III, or RGD peptide, and placed in the femur of goats together with an uncoated reference state. Bone contact and volume were determined after 5 and 12 weeks implantation, using both histomorphometry and synchrotron radiation micro computed tomography (SR mCT) as the methods complement each other: SR mCT allows for a high precision of bone detection due to the large number of analysed slices per sample, while histology offers a better lateral resolution and the possibility of additionally determining bone contact. Both methods revealed similar tendencies in bone formation for the differently bio-functionalized implants, with the SR mCT data resulting in significant differences. After 5 and 12 weeks, all three coatings showed a significant increase in bone volume over the uncoated reference, with the highest results for the collagen coatings. The coating consisting of just the RGD-sequence to improve cell adhesion showed only a slight improvement compar
Who reads Osteoconductive modifications of Ti-implants in a goat defect model: characterization of bone growth with SR μCT and histology?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Ricardo Bernhardt; Juliette van den Dolder; Sussane Bierbaum; Rene Beutner; Dieter Scharnweber; John Jansen; Felix Beckmann; Hartmut Worch
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2005
- Language
- EN
- Field
- Engineering (Physical Sciences)