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Rapid-onset intranasal delivery of metoclopramide hydrochloride: Part II: Safety of various absorption enhancers and pharmacokinetic evaluation by N.M. Zaki; N.D. Mortada; G.A.S. Awad; S.S. Abd ElHady is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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In the present study, several nasal absorption enhancers, used in metoclopramide hydrochloride (MCP HCl) nasal solutions, have been screened for their possible damaging effect in the in vitro human erythrocytes lysis experiment. Moreover, the in vivo leaching of biological markers from the rat nasal epithelium was used as a quantitative assessment for possible nasal mucosal irritation whereby the extent of release of total protein and lactate dehydrogenase (LDH) in the nasal lavage fluid was determined. Results showed that insignificant hemolysis from normal saline (P<0.05) occurred with the enhancer protamine sulphate while poly-l-arginine and sodium cholate demonstrated very low ( 60%) hemolysis in vitro and the release of the biological markers in vivo was significantly higher (P<0.05) than the control solution (no enhancer). A significant correlation (P<0.05) existed between the enhancement effect of MCP HCl nasal absorption and the amounts of protein (r=0.85) and LDH (r=0.88). Furthermore, the pharmacokinetics of MCP HCl was determined after intravenous (IV), per-oral and intranasal administration of 10mg drug dose in rabbits. The application of a nasal spray (NS) solution con

Who reads Rapid-onset intranasal delivery of metoclopramide hydrochloride: Part II: Safety of various absorption enhancers and pharmacokinetic evaluation?

Author

N.M. Zaki; N.D. Mortada; G.A.S. Awad; S.S. Abd ElHady

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2006

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)