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Does N-acetylcysteine improve hemodynamics and graft function in liver transplantation? by Steib, Annick ;Freys, Guy ;Collin, François ;Launoy, Anne ;Mark, Geneviève ;Boudjema, Karim is a Medicine article available to read on EtoBox.

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The release of toxic oxidative free radicals induced by ischemia and reperfusion may jeopardize liver graft function. N-acetylcysteine (NAC) has shown protective effects on hypothermic and warm ischemia reperfusion liver injury in animals. NAC improves hemodynamics and survival rates in patients with fulminant hepatic failure. The aim of this study was to investigate whether intraoperative treatment with NAC would improve hemodynamics and postoperative graft function in liver transplantation. Sixty patients with chronic end-stage liver disease were included in a prospective randomized placebo-controlled study. NAC or the same volume of 5% glucose was started during the anhepatic phase. Hemodynamic data and calculated tissue oxygenation parameters were compared throughout the procedure. Postoperative graft function was assessed by measurements of aminotransferases, prothrombin time, and monoethylglycinexylidide test over the 3 first postoperative days. Patient demographics were similar before the infusion of NAC or glucose. Hemodynamic parameters, oxygen consumption, oxygen delivery, oxygen extraction ratio, and lactates were not different throughout the procedure. One hour after th

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Author

Steib, Annick ;Freys, Guy ;Collin, François ;Launoy, Anne ;Mark, Geneviève ;Boudjema, Karim

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1074-3022)

Published

1998

Language

EN

Field

Medicine (Health Sciences)