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Development of a high-performance liquid chromatography-based assay for carotenoids in human red blood cells: Application to clinical studies by Kiyotaka Nakagawa; Takehiro Kiko; Keijiro Hatade; Akira Asai; Fumiko Kimura; Phumon Sookwong; Tsuyoshi Tsuduki; Hiroyuki Arai; Teruo Miyazawa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Development of a high-performance liquid chromatography-based assay for carotenoids in human red blood cells: Application to clinical studies about?
Membrane phospholipid peroxidation has received attention in relation to oxidative stress occurring during pathophysiological changes such as atherogenesis and aging . We previously confirmed that significantly higher levels of peroxidized phospholipids (i.e., phospholipid hydroperoxides [PLOOHs]) 1 are accumulated in red blood cells (RBCs) of dementia patients . Compounds that can minimize such accumulation may be used therapeutically as effective drugs or functional foods to prevent the disease. Therefore, we carried out animal studies and found carotenoids (Fig. ) as potential compounds to inhibit RBC phospholipid hydroperoxidation .
Who reads Development of a high-performance liquid chromatography-based assay for carotenoids in human red blood cells: Application to clinical studies?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kiyotaka Nakagawa; Takehiro Kiko; Keijiro Hatade; Akira Asai; Fumiko Kimura; Phumon Sookwong; Tsuyoshi Tsuduki; Hiroyuki Arai; Teruo Miyazawa
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0003-2697)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)