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Urinary Symptoms and Prostate Cancer—the Misconception That May Be Preventing Earlier Presentation and Better Survival Outcomes by Gnanapragasam, Vincent J. (author);Greenberg, David (author);Burnet, Neil (author) is a Medicine article available to read on EtoBox.

What is Urinary Symptoms and Prostate Cancer—the Misconception That May Be Preventing Earlier Presentation and Better Survival Outcomes about?

## Background: Prostate cancer is an epidemic of the modern age, and despite efforts to improve awareness, it remains the case that mortality has hardly altered over the decades, driven largely by late presentation. there is a strong public perception that male urinary symptoms is one of the key indicators of prostate cancer, and this continues to be part of messaging from national guidelines and media health campaigns. this narrative, however, is not based on evidence and may be seriously hampering efforts to encourage early presentation. ## Discussion: Anatomically, prostate cancer most often arises in the peripheral zone, while urinary symptoms result from compression of the urethra by prostatic enlargement more centrally. biopsy studies show that mean prostate volume is actually lower in men found to have (early) prostate cancer compared to those with benign biopsies. this inverse relationship between prostate size and the probability of cancer is so strong that psa density (psa corrected for prostate volume) is known to be significantly more accurate in predicting a positive biopsy than psa alone. thus, this disconnect between scientific evidence and the current perception is

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Author

Gnanapragasam, Vincent J. (author);Greenberg, David (author);Burnet, Neil (author)

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)