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Spectroscopic Methods to Detect and Analyze Protein Oligomerization, Aggregation, and Fibrillation by Kummari Shivani; Amrita Arpita Padhy; Subhashree Sahoo; Varsha Kumari; Parul Mishra is a book available to read on EtoBox.

What is Spectroscopic Methods to Detect and Analyze Protein Oligomerization, Aggregation, and Fibrillation about?

Diversity in protein conformations is closely associated with their function. Methods exploring conformation alterations are valuable to harness the disease-relevant changes in protein structure for therapeutic purposes. Although an array of methods are available to analyze tertiary structures in proteins, the quantitative and qualitative analysis of protein conformations is comprehensively studied using multiple spectroscopic methods. Spectroscopic techniques involve the interaction of electromagnetic radiations with proteins in solution. They are discrete in terms of the regions of electromagnetic spectrum utilized for interaction and the properties of the biological sample, which are altered during excitation by radiation. Spectroscopic methods excel in providing information about conformational transitions in both the active soluble and inactive aggregate forms of proteins. This chapter provides an overview of the methodology of various spectroscopic techniques and discusses their application in understanding the structural properties of oligomeric proteins.

Author

Kummari Shivani; Amrita Arpita Padhy; Subhashree Sahoo; Varsha Kumari; Parul Mishra

Publisher

Elsevier

Published

2023

Language

EN