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Glycoprotein Ib/IX complex is the target in rifampicin‐induced immune thrombocytopenia by Jaime Pereira; Patricia Hidalgo; Mauricio Ocqueteau; Marcelo Blacutt; Miguel Marchesse; Yih Nien; Luz Letelier; Diego Mezzano is a Medicine article available to read on EtoBox.

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Thrombocytopenia is a major adverse effect of several drug treatments. Rifampicin has been recognized as a cause of immune thrombocytopenia during intermittent high‐dose therapy. We characterized the antibody of a patient who presented with purpura and thrombocytopenia during treatment of tuberculosis with rifampicin. Drug‐dependent binding of the antibody to platelets was demonstrated by flow cytometry. In a glycoprotein‐specific immunoassay, the binding epitope of the IgG antibody was found in the glycoprotein Ib/IX complex, using four different monoclonal antibodies (mAbs) against various epitopes on the GPIb/IX complex, as well as mAbs against GPIIb/IIIa, GPIa/IIa and GPIV. By immunoprecipitation of biotin‐labelled platelets, reactivity of the antibody with GPIb/IX was found only in the presence of the drug. These findings clearly demonstrate that rifampicin induces the formation of drug‐dependent antibodies capable of causing thrombocytopenia. The binding site of the rifampicin‐dependent antibody, located in the GPIb/IX complex, seems to be a favoured target for antibodies induced by different drugs.

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Author

Jaime Pereira; Patricia Hidalgo; Mauricio Ocqueteau; Marcelo Blacutt; Miguel Marchesse; Yih Nien; Luz Letelier; Diego Mezzano

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2000

Language

EN

Field

Medicine (Health Sciences)