Can I read Genetic Variation at the Uncoupling Protein 1, 2 and 3 Loci and the Response to Long-term Overfeeding on EtoBox?

Genetic Variation at the Uncoupling Protein 1, 2 and 3 Loci and the Response to Long-term Overfeeding by Ukkola, O; Tremblay, A; Sun, G; Chagnon, Y C; Bouchard, C is a Medicine article available to read on EtoBox.

What is Genetic Variation at the Uncoupling Protein 1, 2 and 3 Loci and the Response to Long-term Overfeeding about?

Objective: To evaluate the effects of uncoupling protein (UCP) 1, UCP2 and UCP3 gene variants on body composition and metabolic changes in response to chronic overfeeding and the recovery after the period of overfeeding. Subjects and design: Twenty-four normal weight men (21 AE 2 y), who constituted 12 pairs of identical twins, ate a 4.2 MJ=day energy surplus, 6 days a week, during a period of 100 days. The subjects were asked to return to the laboratory for testing at 4 months and for a final examination 5 y after completion of the overfeeding protocol. Methods: Resting metabolic rate (RMR) measurements were performed before and after overfeeding. A 4.2 MJ test meal was consumed, after which calorimetric measurements were continued for 240 min. Total body fat was assessed by hydrodensitometry and total subcutaneous fat by the sum of eight skinfolds. Polymorphisms were typed by PCR and PCR-RFLP-techniques. Thyroid stimulating hormone (TSH) concentrations after a thyrotropin releasing hormone (TRH) injection were measured by radioimmunoassay (RIA). Results: The changes in body weight and adiposity were not different between UCP1 Bcl I, UCP2 alanine to valine (A55V), UCP2 insertion=d

Who reads Genetic Variation at the Uncoupling Protein 1, 2 and 3 Loci and the Response to Long-term Overfeeding?

Author

Ukkola, O; Tremblay, A; Sun, G; Chagnon, Y C; Bouchard, C

Publisher

Nature Publishing Group; Springer Science and Business Media LLC (ISSN 0954-3007)

Published

2024

Language

EN

Field

Medicine (Health Sciences)