Opening book details…
Can I read High-resolution Imaging of Normal Anatomy, and Neural and Adrenal Malformations in Mouse Embryos Using Magnetic Resonance Microscopy on EtoBox?
High-resolution Imaging of Normal Anatomy, and Neural and Adrenal Malformations in Mouse Embryos Using Magnetic Resonance Microscopy by Jürgen E. Schneider; Simon D. Bamforth; Cassandra R. Farthing; Kieran Clarke; Stefan Neubauer; Shoumo Bhattacharya is a Earth and Planetary Sciences article available to read on EtoBox.
What is High-resolution Imaging of Normal Anatomy, and Neural and Adrenal Malformations in Mouse Embryos Using Magnetic Resonance Microscopy about?
## Abstract An efficient investigation of the effects of genetic or environmental manipulation on mouse development relies on the rapid and accurate screening of a substantial number of embryos for congenital malformations. Here we demonstrate that it is possible to examine normal organ development and identify malformations in mouse embryos by magnetic resonance microscopy in a substantially shorter time than by conventional histology. We imaged embryos in overnight runs of under 9 h, with an operator time of less than 1 h. In normal embryos we visualized the brain, spinal cord, ganglia, eyes, inner ear, pituitary, thyroid, thymus, trachea, bronchi, lungs, heart, kidneys, gonads, adrenals, oesophagus, stomach, intestines, spleen, liver and pancreas. Examination of the brain in embryos lacking the transcriptional coactivator __Cited2__ showed cerebellar and midbrain roof agenesis, in addition to exencephaly. In these embryos we were also able to detect agenesis of the adrenal gland. We confirmed all malformations by histological sectioning. Thus magnetic resonance microscopy can be used to rapidly identify developmental and organ malformations in mutant mouse embryos generated by t
Who reads High-resolution Imaging of Normal Anatomy, and Neural and Adrenal Malformations in Mouse Embryos Using Magnetic Resonance Microscopy?
It is typically read by researchers, students, and practitioners in Earth and Planetary Sciences.
- Author
- Jürgen E. Schneider; Simon D. Bamforth; Cassandra R. Farthing; Kieran Clarke; Stefan Neubauer; Shoumo Bhattacharya
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0021-8782)
- Published
- 2003
- Language
- EN
- Field
- Earth and Planetary Sciences (Physical Sciences)