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Loss of Heterozygosity at Chromosome Regions 22Q11–12 and 11P15.5 in Renal Rhabdoid Tumors by Deborah E. Schofield; J. Bruce Beckwith; Jeffrey Sklar is a Medicine article available to read on EtoBox.

What is Loss of Heterozygosity at Chromosome Regions 22Q11–12 and 11P15.5 in Renal Rhabdoid Tumors about?

Rhabdoid tumors of the kidney are highly malignant neoplasms that occur primarily within the first 3 years of life. Although they are regarded as distinct from Wilms' tumors, their pathogenesis remains unclear. Whereas most cytogenetic studies of these tumors have revealed normal karyotypes, a few reports have indicated abnormalities at chromosome regions 22q and I I p 15.5. We analyzed 30 primary renal rhabdoid tumors for loss of heterozygosity (LOH) at both regions and found that 24 of 30 tumors (80%) had LOH at chromosome arm 22q and that 5 of 30 ( I 7%) had LOH at chromosome band I I p I 5.5. All of the five tumors with LOH at chromosome arm I I p also had LOH at chromosome arm 22q. The data suggest that there is a gene in chromosome 22, probably a tumor suppressor, inactivation of which may be involved in the genesis of renal rhabdoid tumors. A second gene in chromosome segment I I p 15.5, in the region of the putative W 2 gene, may also be involved, in at least a subset of rhabdoid tumors. In addition, five tumors were characterized by microsatellite instability at three or more of 21 loci examined, suggesting a possible role for a replicative error in tumorigenesis or progre

Who reads Loss of Heterozygosity at Chromosome Regions 22Q11–12 and 11P15.5 in Renal Rhabdoid Tumors?

Author

Deborah E. Schofield; J. Bruce Beckwith; Jeffrey Sklar

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

1996

Language

EN

Field

Medicine (Life Sciences)