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Lack of reliability of CA125 response criteria with anti-VEGF molecularly targeted therapy by Nilofer S. Azad; Christina M. Annunziata; Seth M. Steinberg; Lori Minasian; Ahalya Premkumar; Catherine Chow; Herbert L. Kotz; Elise C. Kohn is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND CA125 is an accepted indicator of epithelial ovarian cancer (EOC) response and is used to monitor patients treated with cytotoxic chemotherapy. It is uncertain how CA125 is affected by molecularly targeted drugs. In this pilot study, the authors analyzed the utility of CA125 to predict disease behavior in patients who were receiving sorafenib, a Raf‐kinase/VEGFR2 inhibitor, and bevacizumab, an anti‐VEGF monoclonal antibody. ## METHODS Fifteen of 42 patients had recurrent EOC. Patients received sorafenib 200 mg orally twice daily or D1‐5 of 7 and bevacizumab 5 mg/kg to 10 mg/kg intravenously every 2 weeks for 28‐day cycles. Computed tomography (CT) scans were performed every 2 cycles for restaging, and CA125 was measured monthly. CA125 concentrations were retrospectively analyzed as a function of clinical behavior. ## RESULTS Fourteen of 15 patients had abnormal CA125 concentrations at study entry (median 1056 U/mL; range, 67 U/mL to 9813 U/mL). Seven (47%) patients had partial response by imaging criteria. Five of these 7 patients had partial response by CA125 criteria (71% sensitivity). Eight (53%) patients would have had partial responses if CA125 criter

Who reads Lack of reliability of CA125 response criteria with anti-VEGF molecularly targeted therapy?

Author

Nilofer S. Azad; Christina M. Annunziata; Seth M. Steinberg; Lori Minasian; Ahalya Premkumar; Catherine Chow; Herbert L. Kotz; Elise C. Kohn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2008

Language

EN

Field

Medicine (Health Sciences)