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Can I read On the Early Life Origins of Vulnerability to Opioid Addiction on EtoBox?
On the Early Life Origins of Vulnerability to Opioid Addiction by Sophia C. Levis; Brandon S. Bentzley; Jenny Molet; Jessica L. Bolton; Christina R. Perrone; Tallie Z. Baram; Stephen V. Mahler is a Neuroscience article available to read on EtoBox.
What is On the Early Life Origins of Vulnerability to Opioid Addiction about?
The origins and neural bases of the current opioid addiction epidemic are unclear. Genetics plays a major role in addiction vulnerability, but cannot account for the recent exponential rise in opioid abuse, so environmental factors must contribute. Individuals with history of early life adversity (ELA) are disproportionately prone to opioid addiction, yet whether ELA interacts with factors such as increased access to opioids to directly influence brain development and function, and cause opioid addiction vulnerability, is unknown. We simulated ELA in female rats and this led to a striking opioid addiction-like phenotype. This was characterized by resistance to extinction, increased relapselike behavior, and, as in addicted humans, major increases in opioid economic demand. By contrast, seeking of a less salient natural reward was unaffected by ELA, whereas demand for highly palatable treats was augmented. These discoveries provide novel insights into the origins and nature of reward circuit malfunction that may set the stage for addiction.
Who reads On the Early Life Origins of Vulnerability to Opioid Addiction?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Sophia C. Levis; Brandon S. Bentzley; Jenny Molet; Jessica L. Bolton; Christina R. Perrone; Tallie Z. Baram; Stephen V. Mahler
- Publisher
- Springer Science and Business Media LLC
- Published
- 2019
- Language
- EN
- Field
- Neuroscience (Life Sciences)