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Separate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron by Jens H. Jensen; Haiying Tang; Christina L. Tosti; Srirama V. Swaminathan; Alvaro Nunez; Kristi Hultman; Kamila U. Szulc; Ed X. Wu; Daniel Kim; Sujit Sheth; Truman R. Brown; Gary M. Brittenham is a Medicine article available to read on EtoBox.
What is Separate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron about?
## Abstract A new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: __ferritin iron__, a dispersed, soluble fraction that can be rapidly mobilized, and __hemosiderin iron__, an aggregated, insoluble fraction that serves as a long‐term reserve. The method utilizes multiple spin echo sequences, exploiting the fact that aggregated iron can induce nonmonoexponential signal decay for multiple spin echo sequences. The method is validated in vitro for agarose phantoms, simulating dispersed iron with manganese chloride, and aggregated iron with iron oxide microspheres. To demonstrate feasibility for human studies, preliminary in vivo data from two healthy controls and six patients with transfusional iron overload are presented. For both phantoms and human subjects, conventional __R__~2~ and __R__~2~\* relaxation rates are also measured in order to contrast the proposed method with established MRI iron quantification techniques. Quantification of dispersed (ferritin‐like) iron may provide a new means of monitoring the risk of iron‐induced toxicity in patients with iron overload and, together with quantification of aggregated (hemosid
Who reads Separate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jens H. Jensen; Haiying Tang; Christina L. Tosti; Srirama V. Swaminathan; Alvaro Nunez; Kristi Hultman; Kamila U. Szulc; Ed X. Wu; Daniel Kim; Sujit Sheth; Truman R. Brown; Gary M. Brittenham
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)