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Can I read Impact of recombinant PTH on management of hypoparathyroidism: a systematic review on EtoBox?
Impact of recombinant PTH on management of hypoparathyroidism: a systematic review by Y. Ramakrishnan; H. C. Cocks is a Medicine article available to read on EtoBox.
What is Impact of recombinant PTH on management of hypoparathyroidism: a systematic review about?
The treatment of post-surgical hypoparathyroidism (following thyroid or parathyroid surgery) is challenging. Presently, this condition is treated with calcium and vitamin D supplements rather than replacing the missing parathyroid hormone. Not only is it challenging to maintain normocalcaemia, but concerns of hypercalciuria and ectopic calcification have also been raised using these supplements. There is an ongoing debate whether recombinant parathyroid hormone (rPTH), which as yet is unlicensed for treating hypoPTH, may offer a more physiological solution. The objective of the study was to assess the effectiveness and safety of rPTH in maintaining normocalcaemia and normocalcuria in hypoparathyroidism. This was a systematic review performed using independently developed search strategies including Medline, Embase, CINAHL, Cochrane, Zetoc, conference proceedings and a manual search until 15 July 2014. Data extraction was undertaken by one reviewer (YR). Studies were synthesised through narrative review with tabulation of results. Of 2,141 studies identified, only eleven studies fitted the inclusion criteria. These studies suggest that rPTH is useful in normalising serum calcium lev
Who reads Impact of recombinant PTH on management of hypoparathyroidism: a systematic review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Y. Ramakrishnan; H. C. Cocks
- Publisher
- Springer Science and Business Media LLC
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)