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Sequence and diversity of rhesus monkey T-cell receptor β chain genes by Gene Levinson; Austin L. Hughes; Norman L. Letvin is a Immunology and Microbiology article available to read on EtoBox.

What is Sequence and diversity of rhesus monkey T-cell receptor β chain genes about?

We have sequenced 23 rearranged T-cell receptor beta chain (Tcrb) cDNA clones derived from peripheral blood lymphocytes (PBL) of a rhesus monkey. All of the clones have a variable-diversity-joining-constant (V-D-J-C) rearrangement similar to that of humans. Two rhesus constant (C) region genes were found, each closely resembling human Cb 1 and 2. All of the rhesus J region sequences align well with ten of the 13 reported human J regions. 17 of the 23 rhesus V region sequences could be assigned to families homologous with eight different human families (Vb 1, 2, 6, 7, 8, 9, 13, and 14). The remaining six V region sequences are more distantly related to human Vb 1 and 13. Thus, the organization and sequences of studied rhesus Tcrb chains resemble human homologs. An evolutionary tree analysis revealed paralogous relationships between specific members of the rhesus and human V region families. Analysis of synonymous and nonsynonymous nucleotide sequence differences indicated that the evolution of the presumed major histocompatibility complex (MHC)-contact regions of the Tcrb chains is less constrained than that of the framework regions.

Who reads Sequence and diversity of rhesus monkey T-cell receptor β chain genes?

Author

Gene Levinson; Austin L. Hughes; Norman L. Letvin

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)

Published

1992

Language

EN

Field

Immunology and Microbiology (Life Sciences)