Can I read Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis on EtoBox?

Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis by Takeshi Wada; Atsushi Shiraishi; Satoshi Gando; Kazuma Yamakawa; Seitaro Fujishima; Daizoh Saitoh; Shigeki Kushimoto; Hiroshi Ogura; Toshikazu Abe; Toshihiko Mayumi; Junichi Sasaki; Joji Kotani; Naoshi Takeyama; Ryosuke Tsuruta; Kiyotsugu Takuma; Shin-ichiro Shiraishi; Yasukazu Shiino; Taka-aki Nakada; Kohji Okamoto; Yuichiro Sakamoto; Akiyoshi Hagiwara; Satoshi Fujimi; Yutaka Umemura; Yasuhiro Otomo is a Medicine article available to read on EtoBox.

What is Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis about?

Background: Traumatic brain injury (TBI)-associated coagulopathy is a widely recognized risk factor for secondary brain damage and contributes to poor clinical outcomes. Various theories, including disseminated intravascular coagulation (DIC), have been proposed regarding its pathomechanisms; no consensus has been reached thus far. This study aimed to elucidate the pathophysiology of TBI-induced coagulopathy by comparing coagulofibrinolytic changes in isolated TBI (iTBI) to those in non-TBI, to determine the associated factors, and identify the clinical significance of DIC diagnosis in patients with iTBI. Methods: This secondary multicenter, prospective study assessed patients with severe trauma. iTBI was defined as Abbreviated Injury Scale (AIS) scores ≥4 in the head and neck, and ≤2 in other body parts. Non-TBI was defined as AIS scores ≥4 in single body parts other than the head and neck, and the absence of AIS scores ≥3 in any other trauma-affected parts. Specific biomarkers for thrombin and plasmin generation, anticoagulation, and fibrinolysis inhibition were measured at the presentation to the emergency department (0 h) and 3 h after arrival. Results: We analyzed 34 iTBI and

Who reads Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis?

Author

Takeshi Wada; Atsushi Shiraishi; Satoshi Gando; Kazuma Yamakawa; Seitaro Fujishima; Daizoh Saitoh; Shigeki Kushimoto; Hiroshi Ogura; Toshikazu Abe; Toshihiko Mayumi; Junichi Sasaki; Joji Kotani; Naoshi Takeyama; Ryosuke Tsuruta; Kiyotsugu Takuma; Shin-ichiro Shiraishi; Yasukazu Shiino; Taka-aki Nakada; Kohji Okamoto; Yuichiro Sakamoto; Akiyoshi Hagiwara; Satoshi Fujimi; Yutaka Umemura; Yasuhiro Otomo

Publisher

Frontiers Media SA

Published

2021

Language

EN

Field

Medicine (Health Sciences)