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Feasibility of Sparing Lung and Other Thoracic Structures with Intensity-modulated Radiotherapy for Non–small-cell Lung Cancer by H.Helen Liu; Xiaochun Wang; Lei Dong; Qiuwen Wu; Zhongxing Liao; Craig W Stevens; Thomas M Guerrero; Ritsuko Komaki; James D Cox; Radhe Mohan is a Medicine article available to read on EtoBox.
What is Feasibility of Sparing Lung and Other Thoracic Structures with Intensity-modulated Radiotherapy for Non–small-cell Lung Cancer about?
Purpose: To investigate the possibility of using intensity-modulated radiotherapy (IMRT) to reduce the irradiated volumes of the normal lung and other critical structures in the treatment of non-small-cell lung cancer (NSCLC) and to investigate the effect of IMRT on the potential of spreading low doses to large volumes of normal tissues in such treatment. Methods and Materials: A retrospective treatment planning study was performed to compare IMRT and conventional three-dimensional conformal radiation therapy (3D-CRT) for 10 NSCLC patients (Stage I-IIIB). In the IMRT plans, three to nine coplanar beams were designed to treat 95% of the planning target volume with 63 Gy and to minimize the volumes of the normal lung, esophagus, heart, and spinal cord irradiated above their tolerance doses. The two types of plans were compared with respect to the planning target volume coverage, dose-volume histograms, and other dosimetric indexes of the normal structures. Results: Comparing the nine-beam IMRT plan with the 3D-CRT plan, the percentage of lung volume that received >20 Gy and the mean lung dose were reduced for all cases, with a median reduction of 8% and 2 Gy, respectively. An additio
Who reads Feasibility of Sparing Lung and Other Thoracic Structures with Intensity-modulated Radiotherapy for Non–small-cell Lung Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- H.Helen Liu; Xiaochun Wang; Lei Dong; Qiuwen Wu; Zhongxing Liao; Craig W Stevens; Thomas M Guerrero; Ritsuko Komaki; James D Cox; Radhe Mohan
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)