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In Response to Dr. Merav A. Ben-David et al. (“Lack of Osteoradionecrosis of the Mandible After IMRT,” Int J Radiat Oncol Biol Phys 2007:In Press) by Gabriela Studer; Klaus W. Graetz; Christoph Glanzmann is a Medicine article available to read on EtoBox.

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cancer. They retrospectively analyzed the cranial distribution of Level II neck nodes in patients with laryngeal cancer and performed an outstanding work in providing valuable insight into the optimal strategy for target delineation. However, we pronounce a few concerns regarding this article. First, the investigators stated that the reduction in dose to the parotid gland was achieved in combination with intensity-modulated radiotherapy and lowering the cranial border of Level II nodes by referring to previous series, including Chao et al. (2). In this aspect, we are a bit confused because Chao et al. (2) did not lower the upper limit of Level II and used the cranial base as the superior limit. Second, the investigators concluded that setting the cranial border of Level II nodes 1.5-cm caudally to the base of skull covered 95% of the cranial metastatic nodes and should be considered in elective neck irradiation for patients with laryngeal cancer. They had the chance to evaluate only 67 of 152 patients with laryngeal cancer (44%) with positive neck nodes treated at the same period, and accordingly, we ask how the investigators could be so confident in terms of using such a definite

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Author

Gabriela Studer; Klaus W. Graetz; Christoph Glanzmann

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)