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Can I read Study of a Cyclopamine Glucuronide Prodrug for the Selective Chemotherapy of Glioblastoma on EtoBox?
Study of a Cyclopamine Glucuronide Prodrug for the Selective Chemotherapy of Glioblastoma by Florian Hamon; Brigitte Renoux; Corinne Chadéneau; Jean-Marc Muller; Sébastien Papot is a Chemistry article available to read on EtoBox.
What is Study of a Cyclopamine Glucuronide Prodrug for the Selective Chemotherapy of Glioblastoma about?
The first glucuronide prodrug of the hedgehog signaling inhibitor cyclopamine was synthesized. The carbamoyl derivatisation of cyclopamine significantly decreased its toxicity towards the U87 human glioblastoma cell line. However, when the prodrug was incubated with β-glucuronidase in the culture media, the active drug was efficiently released thereby restoring its anti-proliferative activity.
Who reads Study of a Cyclopamine Glucuronide Prodrug for the Selective Chemotherapy of Glioblastoma?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Florian Hamon; Brigitte Renoux; Corinne Chadéneau; Jean-Marc Muller; Sébastien Papot
- Publisher
- Elsevier BV
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)