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O-acetylation of sialic acids in N-glycans of Atlantic salmon (Salmo salar) serum is altered by handling stress by Xin Liu; Luis Afonso; Eleonora Altman; Stewart Johnson; Laura Brown; Jianjun Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract __O__‐acetylation is one of the major modifications of sialic acids that significantly alters biological properties of the parent molecule. These __O__‐acetylated forms are components of the cellular membrane and can affect physiological and pathological responses. Understanding the role of __N__‐glycans in physiology is of increasing relevance to cellular biologists in various disciplines who study glycoproteomics yet lack information regarding the function of the attached glycans. It is well known that stress may decrease immune function in fish; however, there are only few suitable biomarkers available to monitor the physiological responses under the stress conditions. This study is the first report on the effect of stress on the profile of __O__‐acetylation of sialic acids in fish serum. In order to preserve the relevant structural characteristics as much as possible, native __N__‐glycans were directly analyzed using CE‐MS. We have characterized the __N__‐glycans in serum of salmon (__Salmo salar__) exposed to long‐term handling stress (15 s out of the water, daily for 4 wk) and compared with the results obtained from sera of control fish. The results indicated that

Who reads O-acetylation of sialic acids in N-glycans of Atlantic salmon (Salmo salar) serum is altered by handling stress?

Author

Xin Liu; Luis Afonso; Eleonora Altman; Stewart Johnson; Laura Brown; Jianjun Li

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)