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Brain and Behavioral Alterations in Subjects with Social Anxiety Dominated by Empathic Embarrassment by Shisei Tei; Jukka-Pekka Kauppi; Kathryn F. Jankowski; Junya Fujino; Ricardo P. Monti; Jussi Tohka; Nobuhito Abe; Toshiya Murai; Hidehiko Takahashi; Riitta Hari is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Brain and Behavioral Alterations in Subjects with Social Anxiety Dominated by Empathic Embarrassment about?

## Significance People are increasingly affected by social anxiety that includes emotional hypersensitivity and inaccurate interpretation of social encounters, and varies markedly in its subjective manifestations. We searched for insights into the underlying neurocognitive mechanisms of Taijin-kyofusho (TKS), a specific subtype of social-anxiety disorder common in East Asia and dominated by empathic or other-oriented embarrassment. We found TKS to be characterized by enhanced affective and reduced cognitive empathy. Moreover, analysis of functional MRI data—collected while subjects viewed videos of badly singing people—revealed disruption of the cognitive–empathy network, possibly obstructing flexible inference of others’ perspective or augmenting maladaptive feelings of embarrassment. Our findings shed light on how altered affective and cognitive processing can contribute to the development of imaginary fears.

Who reads Brain and Behavioral Alterations in Subjects with Social Anxiety Dominated by Empathic Embarrassment?

Author

Shisei Tei; Jukka-Pekka Kauppi; Kathryn F. Jankowski; Junya Fujino; Ricardo P. Monti; Jussi Tohka; Nobuhito Abe; Toshiya Murai; Hidehiko Takahashi; Riitta Hari

Publisher

Proceedings of the National Academy of Sciences

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)