Can I read Deviance Detection and Regularity Sensitivity in Dissociated Neuronal Cultures on EtoBox?

Deviance Detection and Regularity Sensitivity in Dissociated Neuronal Cultures by Zhang, Zhuo; Yaron, Amit; Akita, Dai; Shiramatsu, Tomoyo Isoguchi; Chao, Zenas C.; Takahashi, Hirokazu is a scholarly article available to read on EtoBox.

What is Deviance Detection and Regularity Sensitivity in Dissociated Neuronal Cultures about?

Understanding how neural networks process complex patterns of information is crucial for advancing both neuroscience and artificial intelligence. To investigate fundamental principles of neural computation, we studied dissociated neuronal cultures, one of the most primitive living neural networks, on high-resolution CMOS microelectrode arrays and tested whether the dissociated culture exhibits regularity sensitivity beyond mere stimulus-specific adaptation and deviance detection. In oddball electrical stimulation paradigms, we confirmed that the neuronal culture produced mismatch responses (MMRs) with true deviance detection beyond mere adaptation. These MMRs were dependent on the N-methyl-D-aspartate (NMDA) receptors, similar to mismatch negativity (MMN) in humans, which is known to have true deviance detection properties. Crucially, we also showed sensitivity to the statistical regularity of stimuli, a phenomenon previously observed only in intact brains: the MMRs in a predictable, periodic sequence were smaller than those in a commonly used sequence in which the appearance of the deviant stimulus was random and unpredictable. These results challenge the traditional view that a h

Author

Zhang, Zhuo; Yaron, Amit; Akita, Dai; Shiramatsu, Tomoyo Isoguchi; Chao, Zenas C.; Takahashi, Hirokazu

Published

2025

Language

EN