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Enhanced blood compatibility of polymers grafted by sulfonated PEO via a negative cilia concept by Young Ha Kim; Dong Keun Han; Ki Dong Park; Soo Hyun Kim is a Engineering article available to read on EtoBox.

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In our laboratory sulfonated PEO (PEO-SO(3)) was designed as a "negative cilia model" to investigate a synergistic effect of PEO and negatively charged SO(3) groups. PEO-SO(3) itself exhibited a heparin-like anticoagulant activity of 14% of free heparin. Polyurethane grafted with PEO-SO(3) (PU-PEO-SO(3)) increased the albumin adsorption to a great extent but suppressed other proteins, while PU-PEO decreased the adsorption of all the proteins. The platelet adhesion was decreased on PU-PEO but least on PU-PEO-SO(3) to demonstrate an additional effect of SO(3) groups. The enhanced blood compatibility of PU-PEO-SO(3) in the ex vivo rabbit and in vivo canine implanting tests was confirmed. Furthermore, PU-PEO-SO(3) exhibited an improved biostability and suppressed calcification in addition to the enhanced antithrombogenicity. The in vivo antithrombogenicity and biostability were improved in the order of PUPU-PEO>PU-PEO-SO(3) in spite of the possible attraction between negative SO(3) groups and positive calcium ions. The bioprosthetic tissue (BT) was grafted with H(2)N-PEO-SO(3) via glutaraldehyde (GA) residues after conventional GA fixation. BT-PEO-SO(3) also displayed the decreased cal

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Author

Young Ha Kim; Dong Keun Han; Ki Dong Park; Soo Hyun Kim

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2003

Language

EN

Field

Engineering (Physical Sciences)