About this Neuroscience article
Sporadic obstructive hydrocephalus in Aqp4 null mice by Xuechao Feng; Marios C. Papadopoulos; Jun Liu; Lihua Li; Di Zhang; Hongguo Zhang; A. S. Verkman; Tonghui Ma is a Neuroscience article available to read on EtoBox.
## Abstract Aquaporin‐4 (Aqp4) is a water transport protein expressed in glia and ependymocytes in brain. We report here the unexpected occurrence of severe obstructive hydrocephalus in a random subset of __Aqp4__ knockout mice. Of 612 __Aqp4__ knockout mice produced by heterozygote–heterozygote or knockout–knockout breedings, 9.6% of offspring manifested progressive encephalomegaly. Encephalomegaly was never seen in wild‐type or __Aqp4__ heterozygous mice. Examination of the subset encephalomegalic mice revealed marked triventricular hydrocephalus (lateral ventricle size ∼500 mm^3^), elevated intracranial pressure (19 ± 3 vs. 6.1 ± 0.6 mm Hg), and death by age 6 weeks, with a median survival of 28 days. Intraventricular dye injection studies revealed total obstruction of the cerebral aqueduct. Evans blue extravasation studies indicated an intact blood–brain barrier in the hydrocephalic mice. Brain histology revealed reduced ventricular size and ependymocyte disorganization in some nonhydrocephalic __Aqp4__ null mice. Our studies establish __Aqp4__ deletion as a predisposing factor for the development of congenital obstructive hydrocephalus in mice. We suggest that __AQP4__ polymor
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Xuechao Feng; Marios C. Papadopoulos; Jun Liu; Lihua Li; Di Zhang; Hongguo Zhang; A. S. Verkman; Tonghui Ma
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2008
- Language
- EN
- Field
- Neuroscience (Life Sciences)