Can I read Gadolinium-based Cancer Therapeutic Liposomes for Chemotherapeutics and Diagnostics on EtoBox?

Gadolinium-based Cancer Therapeutic Liposomes for Chemotherapeutics and Diagnostics by Kyunga Na; Seul A Lee; Suk Hyun Jung; Byung Cheol Shin is a Materials Science article available to read on EtoBox.

What is Gadolinium-based Cancer Therapeutic Liposomes for Chemotherapeutics and Diagnostics about?

Gadolinium (Gd)-based cancer therapeutic liposomes can be used for chemotherapeutics and diagnostics. In this study, dual functional liposomes co-encapsulating doxorubicin (Dox) and Gd were prepared by Dox-transition metal complexation. Preparation conditions were optimized to obtain liposomes containing high concentrations of Dox and Gd. The optimized liposomes Gd250 co-encapsulated 3.6 mM of Dox and 1.9 mM of Gd. The magnetic resonance (MR) properties of Gd250 liposomes were determined using a 4.7 T MR system. Cellular uptake of Dox was determined using a flow cytometer and a confocal microscopy and that of Gd was measured using an inductively coupled plasma-atomic emission spectrometer. Although encapsulated Gd exhibited lower relaxivity than MRbester ® , which is widely used for clinical diagnosis, because of limited diffusion across the liposome membrane, Gd250 liposomes showed much higher cellular uptake than that of MRbester ® . In Gd250 liposomes, Gd was highly accumulated in B16F10 cells, which could provide improved contrast sensitivity for molecular imaging. Additionally, in Gd250 liposomes, Dox was highly internalized, which could enhance its cancer therapeutic effects.

Who reads Gadolinium-based Cancer Therapeutic Liposomes for Chemotherapeutics and Diagnostics?

Author

Kyunga Na; Seul A Lee; Suk Hyun Jung; Byung Cheol Shin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2011

Language

EN

Field

Materials Science (Physical Sciences)