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What is Fundamentals of DNA and RNA Structure about?

In 1946, Avery provided concrete experimental evidence that DNA was the main constituent of genes (Avery, MacLeod, and McCarthy, 1944); universal acceptance of this idea came with the publication of the Hershey-Chase experiments (Hershey and Chase, 1951). After the seminal discovery of the double helical nature of DNA in 1953 (Watson andCrick, 1953), the focus of nucleic acid structural research turned to fiber diffraction of natural and defined sequences (Arnott, 1970;Arnott, Campbell, Smith, and Chandrasekaran, 1976). Through these studies, we gained many insights into nucleic acid structure. We learned that hydration, ionic strength, and sequence all affect conformation type, and that nucleic acids can adopt a wide variety of structures, including single-stranded helices (Arnott, Chandrasekaran, and Leslie, 1976) and parallel helices (Rich et al., 1961), as well as triple and quadruple helices (Arnott, Chandrasekaran, and Marttila, 1974). Once it was possible to synthesize and purify oligonucleotides (Khorana, Tener, and Moffatt, 1956), the use of crystallography and later NMR to determine nucleic acid structures became a reality. The first crystal structure that contained all t

Author

Stephen Neidle; Bohdan Schneider; Helen M. Berman

Publisher

Hoboken, N.j. : Wiley-liss, C2003.

Published

2003

Language

EN

ISBN

9780471202004

Subjects

Medical, Science, Chemistry