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Can I read The Effects of Reboxetine and Amitriptyline, with and Without Alcohol on Cognitive Function and Psychomotor Performance on EtoBox?
The Effects of Reboxetine and Amitriptyline, with and Without Alcohol on Cognitive Function and Psychomotor Performance by J. S. KERR; J. POWELL; I. HINDMARCH is a Medicine article available to read on EtoBox.
What is The Effects of Reboxetine and Amitriptyline, with and Without Alcohol on Cognitive Function and Psychomotor Performance about?
Reboxetine is a novel antidepressant that has been shown to be effective in the treatment of major depressive disorders. The present experiment was designed to assess whether it affects the cognitive and psychomotor skills necessary for optimum function in everyday life. Ten healthy male volunteers received reboxetine 0.5 mg, 1 mg or 4 mg, amitriptyline 25 mg, or matched placebo with and without alcohol (0.6 mg kg^−1^) in a double‐blind 10‐way crossover study. A psychometric test battery was administered at baseline and at 1, 2.25, 3.5, 6 and 9 h post‐dose. The results showed that reboxetine had little or no effect on performance at any dose, compared with placebo. Amitriptyline, however, with and without alcohol, lowered critical flicker fusion threshold compared with placebo and/or reboxetine at all test points (e.g. at 3.5 h: 28.51 __vs__ 30.33 Hz; __P__<0.05); increased reaction time (e.g. 619 __vs__ 540 ms; __P__<0.05); increased tracking error (e.g. 16.34 __vs__ 8.54 RMS units; __P__<0.05); and slowed short‐term memory scanning (e.g. 742 __vs__ 590 ms; __P__<0.05). It is concluded that reboxetine at doses of 4 mg and below is free from disruptive effects on cognitive function
Who reads The Effects of Reboxetine and Amitriptyline, with and Without Alcohol on Cognitive Function and Psychomotor Performance?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- J. S. KERR; J. POWELL; I. HINDMARCH
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)