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This study evaluates mitochondrial toxicity induced by both parent drugs and their metabolites using CYP-introduced HepG2 cells, addressing a gap in previous research that primarily focused on parent forms. The findings indicate that certain compounds, previously linked to liver injury, exhibit metabolite-induced mitochondrial toxicities, highlighting the utility of this in vitro system for predicting drug-induced liver injury (DILI) in preclinical phases. The developed TC-Hep cells demonstrate stable expre

Author

6s84xmnpsk

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EN