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Tandem‐pore domain potassium channels are functionally expressed in retinal (Müller) glial cells by S.N. Skatchkov; M.J. Eaton; Y.M. Shuba; Y.V. Kucheryavykh; C. Derst; R.W. Veh; A. Wurm; I. Iandiev; T. Pannicke; A. Bringmann; A. Reichenbach is a Neuroscience article available to read on EtoBox.
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## Abstract Tandem‐pore domain (2P‐domain) K^+^‐channels regulate neuronal excitability, but their function in glia, particularly, in retinal glial cells, is unclear. We have previously demonstrated the immunocytochemical localization of the 2P‐domain K^+^ channels TASK‐1 and TASK‐2 in retinal Müller glial cells of amphibians. The purpose of the present study was to determine whether these channels were functional, by employing whole‐cell recording from frog and mammalian (guinea pig, rat and mouse) Müller cells and confocal microscopy to monitor swelling in rat Müller cells. TASK‐like immunolabel was localized in these cells. The currents mediated by 2P‐domain channels were studied in isolation after blocking Kir, K~A~, K~D~, and BK channels. The remaining cell conductance was mostly outward and was depressed by acid pH, bupivacaine, methanandamide, quinine, and clofilium, and activated by alkaline pH in a manner consistent with that described for TASK channels. Arachidonic acid (an activator of TREK channels) had no effect on this conductance. Blockade of the conductance with bupivacaine depolarized the Müller cell membrane potential by about 50%. In slices of the rat retina, ade
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- Author
- S.N. Skatchkov; M.J. Eaton; Y.M. Shuba; Y.V. Kucheryavykh; C. Derst; R.W. Veh; A. Wurm; I. Iandiev; T. Pannicke; A. Bringmann; A. Reichenbach
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2005
- Language
- EN
- Field
- Neuroscience (Life Sciences)