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Changes in White Matter Microstructure Over 3 Years in People With and Without Stroke by Natalia Egorova-Brumley; Thijs Dhollander; Wasim Khan; Mohamed Salah Khlif; Deena Ebaid; Amy Brodtmann is a Medicine article available to read on EtoBox.

What is Changes in White Matter Microstructure Over 3 Years in People With and Without Stroke about?

Background and Objectives: Cerebral white matter health can be estimated by MRI-derived indices of microstructure. White matter dysfunction is increasingly recognized as a contributor to neurodegenerative disorders affecting cognition and to functional outcomes after stroke. Reduced indices of white matter microstructure have been demonstrated cross-sectionally in stroke survivors compared to stroke-free participants, but longitudinal changes in the structure of white matter after stroke remain largely unexplored. We aimed to characterise white matter micro- and macrostructure over 3 years after stroke and study associations with white matter metrics and cognitive functions. Methods: Patients with first-ever or recurrent ischemic stroke of any etiology in any vascular territory were compared with stroke-free age- and sex-matched controls. Those diagnosed with hemorrhagic stroke, transient ischemic attack, venous infarction, or significant medical comorbidities, psychiatric and neurodegenerative disorders, substance abuse, or history of dementia were excluded. Diffusion-weighted MRI data at 3, 12 and 36 months were analysed using a longitudinal “fixel”-based analysis, sensitive to f

Who reads Changes in White Matter Microstructure Over 3 Years in People With and Without Stroke?

Author

Natalia Egorova-Brumley; Thijs Dhollander; Wasim Khan; Mohamed Salah Khlif; Deena Ebaid; Amy Brodtmann

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Language

EN

Field

Medicine (Health Sciences)