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Presymptomatic Testing for Adult Onset Polycystic Kidney Disease in At-risk Kidney Transplant Donors by Vickie L. Hannig; Jeanne R. Hopkins; H. Keith Johnson; John A. Phillips III; Stephen T. Reeders is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Presymptomatic Testing for Adult Onset Polycystic Kidney Disease in At-risk Kidney Transplant Donors about?

Autosomal dominant adult-onset polycystic kidney disease (ADPKD) is estimated to have an incidence of 1/1,000 and accounts for approximately 10% of all end-stage renal disease in the United States. While relatives are attractive as renal donors due to their availability and the improved transplant success associated with livingrelated donors, they may coincidentally be at risk for ADPKD. Accurate presymptomatic testing for at-risk potential donors is critical for both the donor and the recipient. We report here 2 families in which presymptomatic testing for ADPKD was accomplished by DNA linkage analysis on several potential renal donors prior to transplant. This resulted in the protection of both donors and recipients by preventing the transplantation of a kidney affected by AD-PKD. Thorough counseling prior to DNA analysis (including discussion of accuracy and possible testing outcomes of presymptomatic diagnosis of ADPKD, diagnosis of noncarrier status, false paternity, and noninformative study) was essential to provide informed consent and preserve confidentiality within the family. Confidentiality for potential donors found presymptomatically to be affected (with a 94% or great

Who reads Presymptomatic Testing for Adult Onset Polycystic Kidney Disease in At-risk Kidney Transplant Donors?

Author

Vickie L. Hannig; Jeanne R. Hopkins; H. Keith Johnson; John A. Phillips III; Stephen T. Reeders

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)

Published

1991

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)