Opening book details…
Can I read Targeting Glycosylation Pathways and the Cell Cycle: Sugar-Dependent Activity of Butyrate-Carbohydrate Cancer Prodrugs on EtoBox?
Targeting Glycosylation Pathways and the Cell Cycle: Sugar-Dependent Activity of Butyrate-Carbohydrate Cancer Prodrugs by Srinivasa-Gopalan Sampathkumar; Mark B. Jones; M. Adam Meledeo; Christopher T. Campbell; Sean S. Choi; Kaoru Hida; Prasra Gomutputra; Anthony Sheh; Tim Gilmartin; Steven R. Head; Kevin J. Yarema is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Targeting Glycosylation Pathways and the Cell Cycle: Sugar-Dependent Activity of Butyrate-Carbohydrate Cancer Prodrugs about?
Short-chain fatty acid (SCFA)-carbohydrate hybrid molecules that target both histone deacetylation and glycosylation pathways to achieve sugar-dependent activity against cancer cells are described in this article. Specifically, n-butyrate esters of N-acetyl-D-mannosamine (But 4 ManNAc, 1) induced apoptosis, whereas corresponding N-acetyl-D-glucosamine (But 4 GlcNAc, 2), D-mannose (But 5 Man, 3), or glycerol (tributryin, 4) derivatives only provided transient cell cycle arrest. Western blots, reporter gene assays, and cell cycle analysis established that n-butyrate, when delivered to cells via any carbohydrate scaffold, functioned as a histone deacetylase inhibitor (HDACi), upregulated p21 WAF1/Cip1 expression, and inhibited proliferation. However, only 1, a compound that primed sialic acid biosynthesis and modulated the expression of a different set of genes compared to 3, ultimately killed the cells. These results demonstrate that the biological activity of butyrate can be tuned by sugars to improve its anticancer properties.
Who reads Targeting Glycosylation Pathways and the Cell Cycle: Sugar-Dependent Activity of Butyrate-Carbohydrate Cancer Prodrugs?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Srinivasa-Gopalan Sampathkumar; Mark B. Jones; M. Adam Meledeo; Christopher T. Campbell; Sean S. Choi; Kaoru Hida; Prasra Gomutputra; Anthony Sheh; Tim Gilmartin; Steven R. Head; Kevin J. Yarema
- Publisher
- Elsevier Science; Elsevier ; Cell Press; Elsevier BV (ISSN 1074-5521)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)