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Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model by Robert Kotloski; James O. McNamara is a Neuroscience article available to read on EtoBox.

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## Abstract Elucidating the mechanisms of epileptogenesis in molecular terms can identify targets for therapies aimed at preventing epileptogenesis or limiting its progression. Genetic perturbations have implicated signaling by the neurotrophin, BDNF, and its receptor, TrkB, in limbic epileptogenesis. Whether this signaling is critical to epileptogenesis in the adult brain is unclear. We sought to determine whether reduced expression of TrkB de novo in the mature brain is sufficient to impair epileptogenesis in the kindling model. Treatment of adult __Act‐CreER TrkB__^__flox/flox__^ mice with tamoxifen resulted in modest reductions of TrkB protein expression de novo in the adult that were detected in hippocampus but not other brain regions. Modest reduction of hippocampal TrkB content inhibited epileptogenesis induced by stimulation of hippocampus or amygdala. The data support the conclusion that reduction of TrkB expression in hippocampus de novo in the mature brain impairs epileptogenesis in the kindling model. These findings advance TrkB and its downstream signaling pathways as attractive targets for limiting the progression of epileptogenesis. © 2009 Wiley‐Liss, Inc.

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Author

Robert Kotloski; James O. McNamara

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)