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Can I read Blood group abh-related antigens in normal and malignant bladder urothelium: Possible structural basis for the deletion of type-2 chain abh antigens in invasive carcinomas on EtoBox?
Blood group abh-related antigens in normal and malignant bladder urothelium: Possible structural basis for the deletion of type-2 chain abh antigens in invasive carcinomas by Torben F. Ørntoft; Hans Wolf; Henrik Clausen; Erik Dabelsteen; Sen-Itiroh Hakomori is a Medicine article available to read on EtoBox.
What is Blood group abh-related antigens in normal and malignant bladder urothelium: Possible structural basis for the deletion of type-2 chain abh antigens in invasive carcinomas about?
A complete panel of mouse monoclonal antibodies (MAbs) against Type-2 chain (GalQ I -4GlcNAc-R) blood-group antigens (N-acetyl-lactosamine, Le", H, Ley, A monofucosylated, A h Y , repetitive A) was used in a detailed immunohistological study of the modulation of these carbohydrate antigens in transitional-cell carcinomas. The histological and cellular lo- cations of these antigens were studied in 19 normal bladder biopsies and 53 transitional-cell carcinomas with as well as without neuraminidase treatment of tissue sections in order to uncover potential sialylated antigens. The antigen expression was correlated to individual A,A,BO, Lewis, and secretor status. Several alterations of blood group expression were found: (I) loss of A and H antigens with accumulation of Ley antigens; (2) loss of correlation between antigen expression and secretor status; (3) disruption of the orderly stratification of blood-group antigen expression in relation to cell layers; and (4) changes in subcellular location of antigen expression. The present data indicate that deletion of Type-2 chain ABH antigens in transitional-cell carcinomas is associated with Q 1-3 fucosylation of the H antigen leading to
Who reads Blood group abh-related antigens in normal and malignant bladder urothelium: Possible structural basis for the deletion of type-2 chain abh antigens in invasive carcinomas?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Torben F. Ørntoft; Hans Wolf; Henrik Clausen; Erik Dabelsteen; Sen-Itiroh Hakomori
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1989
- Language
- EN
- Field
- Medicine (Health Sciences)