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Atipamezole, an α2-Adrenoceptor Antagonist, Has Disease Modifying Effects on Epileptogenesis in Rats by Asla Pitkänen; Susanna Narkilahti; Zinayida Bezvenyuk; Antti Haapalinna; Jari Nissinen is a Medicine article available to read on EtoBox.

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Stimulation of ␣ 2 -adrenoceptors delays the development of kindling, a model of epileptogenesis in humans. Blocking ␣ 2adrenoceptors is proconvulsant, but has beneficial effects on somatomotor recovery after experimental stroke. We investigated whether atipamezole, a selective ␣ 2 -adrenoceptor antagonist, affects the recovery process from status epilepticus (SE)-induced brain damage, which affects the risk of epileptogenesis. Vehicle or atipamezole (100 g/kg/h) treatment was started 1 week after the induction of SE and continued for 9 weeks using Alzet minipumps (n = 70). Development and severity of epilepsy, spatial and emotional learning, and histologic analysis were used as outcome measures. There were no differences in the percentage of animals with epilepsy in the different treatment groups. In the atipamezole group, however, daily seizure frequency was lower (P < 0.01), a higher percentage of epileptic animals had mild epilepsy (<1 seizure/day; P < 0.01), and seizure frequency did not increase over time compared with the vehicle group. The atipamezole group had milder hilar cell damage (P < 0.05) and less intense mossy fiber sprouting (P < 0.05). Behavioral impairments were

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Author

Asla Pitkänen; Susanna Narkilahti; Zinayida Bezvenyuk; Antti Haapalinna; Jari Nissinen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2004

Language

EN

Field

Medicine (Health Sciences)