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Novel AI-Based Quantification of Breast Arterial Calcification to Predict Cardiovascular Risk by Dapamede, Theodorus; Urooj, Aisha; Joshi, Vedant; Gershon, Gabrielle; Li, Frank; Chavoshi, Mohammadreza; Brown-Mulry, Beatrice; Isaac, Rohan Satya; Mansuri, Aawez; Robichaux, Chad; Ayoub, Chadi; Arsanjani, Reza; Sperling, Laurence; Gichoya, Judy; van Assen, Marly; ONeill, Charles W.; Banerjee, Imon; Trivedi, Hari is a scholarly article available to read on EtoBox.

What is Novel AI-Based Quantification of Breast Arterial Calcification to Predict Cardiovascular Risk about?

Women are underdiagnosed and undertreated for cardiovascular disease. Automatic quantification of breast arterial calcification on screening mammography can identify women at risk for cardiovascular disease and enable earlier treatment and management of disease. In this retrospective study of 116,135 women from two healthcare systems, a transformer-based neural network quantified BAC severity (no BAC, mild, moderate, and severe) on screening mammograms. Outcomes included major adverse cardiovascular events (MACE) and all-cause mortality. BAC severity was independently associated with MACE after adjusting for cardiovascular risk factors, with increasing hazard ratios from mild (HR 1.18-1.22), moderate (HR 1.38-1.47), to severe BAC (HR 2.03-2.22) across datasets (all p<0.001). This association remained significant across all age groups, with even mild BAC indicating increased risk in women under 50. BAC remained an independent predictor when analyzed alongside ASCVD risk scores, showing significant associations with myocardial infarction, stroke, heart failure, and mortality (all p<0.005). Automated BAC quantification enables opportunistic cardiovascular risk assessment during routin

Author

Dapamede, Theodorus; Urooj, Aisha; Joshi, Vedant; Gershon, Gabrielle; Li, Frank; Chavoshi, Mohammadreza; Brown-Mulry, Beatrice; Isaac, Rohan Satya; Mansuri, Aawez; Robichaux, Chad; Ayoub, Chadi; Arsanjani, Reza; Sperling, Laurence; Gichoya, Judy; van Assen, Marly; ONeill, Charles W.; Banerjee, Imon; Trivedi, Hari

Published

2025

Language

EN