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Polydopamine Constructed Interfacial Molecular Bridge in Nano-hydroxylapatite/polycaprolactone Composite Scaffold by Pei Feng; Xiang Qiu; Liuyimei Yang; Qing Liu; Can Zhou; Yongbin Hu; Cijun Shuai is a Materials Science article available to read on EtoBox.

What is Polydopamine Constructed Interfacial Molecular Bridge in Nano-hydroxylapatite/polycaprolactone Composite Scaffold about?

Nano-hydroxylapatite (nano-HAP)/polycaprolactone (PCL) composite scaffold is proved to possess great potential for bone tissue engineering application since the biocompatibility of PCL and the osteoinduction ability of nano-HAP. However, the interfacial bonding between nano-HAP and PCL is weak by reason of the difference in thermodynamic properties. Herein, nano-HAP was modified by polydopamine (PDA) and then added to the PCL matrix to enhance their interface bonding in bone scaffold manufactured by selective laser sintering (SLS). The results indicated that PDA acted as an interfacial molecular bridge between PCL and nano-HAP. On one hand, the amino groups of PDA formed hydrogen bonding with the hydroxyl groups of nano-HAP, and on the other hand, the catechol groups of PDA formed hydrogen bonding with the ester groups of PCL. Compared with the HAP/PCL scaffolds, the tensile and compressive strength of the P-HAP/PCL scaffolds loading 12 wt% P-HAP were increased by 10% and 16%, respectively. Meanwhile, the scaffold possessed great bioactivity and cytocompatibility that could accelerate the formation of apatite layers and promote the cell adhesion, proliferation and differentiation.

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Author

Pei Feng; Xiang Qiu; Liuyimei Yang; Qing Liu; Can Zhou; Yongbin Hu; Cijun Shuai

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)